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MesoRFA Information and Press Releases

Working on a cure for Mesothelioma

Second Round of Chemotherapy May Not Help

According to a study by Turkish researchers, a second round of chemotherapy may not do much good for mesothelioma patients whose cancer returns after first-line treatment.

Chemotherapy CRS-207 mesothelioma vaccinationTheir findings are based on an analysis of 51 pleural mesothelioma patients from a Turkish hospital. All patients in the study were initially treated with chemotherapy, the standard first-line treatment for mesothelioma. But, when their mesothelioma tumors began to grow again several months later, some patients were treated with second-line chemotherapy (SLCT) while others had best supportive care (BSC), which includes symptom management only.

Chemotherapy Standard Is Tough

While chemotherapy is a standard first-line treatment for mesothelioma, an aggressive cancer of the mesothelial membranes, there is disagreement within the medical community as to whether or not second-line chemotherapy is effective. While it can sometimes slow the progression of mesothelioma, chemotherapy is also hard on the body and causes a range of dangerous side effects. For this reason, only the healthiest patients are even considered candidates for second-line chemotherapy.

Chemotherapy Survival Rates

In the Turkish study, patients who had chemotherapy as both a first- and second-line treatment had a median overall survival of 20.3 months. These patients had a median survival of 5.9 months after the end of their first-line chemotherapy. Patients who had only BSC when their mesothelioma began to grow again had a median overall survival of 14.7 months. The median overall survival for these patients from the end of their first-line chemotherapy treatment was 4.7 months.

While the figures seem to show that the second-line chemotherapy patients had better outcomes than those receiving BSC, the authors of the study say the differences between the two are not statistically significant. In addition, the fact that second-line chemotherapy is usually reserved for select patients may also contribute to the apparent skew of the results. They conclude, Our results do not support the proposal that second-line chemotherapy could be effective in patients with malignant pleural mesothelioma.”

While such studies can help guide mesothelioma treatment planning, treatment decisions are made on a case-by-case basis, based on a range of criteria. The original study appears in the Asian Pacific Journal for Cancer Prevention. (Mutlu, H, et al,
Secondline chemotherapy versus best supportive care in patients with malignant pleural mesothelioma: a retrospective study
2013
Asian Pacific Journal of Cancer Prevention
pp. 3887-3889
http://www.apocpcontrol.org/page/apjcp_issues_view.php?no=4654&gubun=p&s_search=mesothelioma&s_paper_vol=14&s_number33=6

4 April 2014 at 11:03 - Comments

No Short Cut to Accomplishments with Stem-Cell Therapy: Research Studies Might Get Retracted

Immunotherapy cancer stem-cell

Some recent research that specified a faster and simpler method for making stem-cell s just might get retracted because one of the two scientists involved in the research project has expressed doubts about the premises regarding their experiments.

It was Teruhiko Wakayama, a researcher at the University of Yamanashi, Japan, who stated he was no longer certain about the premise of the data he used.  During an interview with Japan’s largest international news service, NHK World, Mr. Wakyama said his research studies should be withdrawn from review.  His comments with the NHK news service emphasize the peer pressure that medical researchers experience with Japan’s push into stem-cell science subsequent to the Nobel Prize won by Shinya Yamanaka from KyotoUniversity in 2012.

Early Stem-Cell Therapy Developments

Basically, during an embryo’s early stages of development, stem cells are pluripotent, which mean they can become any type of tissue in a patient’s body.   As the embryo continues to develop, the stem-cell s begin to specialize by differentiation into units for the body’s different tissue structures.

There are currently several ways to regenerate pluripotent stem cells, including one method that uses embryos and another method that reprograms matured stem cells by inserting genes.

However, the controversial studies submitted by Mr. Wakyama discovered that ordinary cells taken from newborn mice could be transformed into stem-cell s without adding genes.   Instead, researchers (led by Haruko Obokata at the RikenCenter for Developmental Biology) shocked the cells with a dose of “sublethal stress” like mechanical force to trigger the transformation into stem-cell s.

According to Nissim Benvenisty, director of the stem-cell therapy laboratory at HebrewUniversity in Jerusalem:

“The study surprised me when it came out because it contradicted the common sense that we have acquired so far in the field.  At the same time, this is the beauty of the scientific world, in which editors allow publication of papers that contradict common sense to allow novel data to be discussed and understood.”

Global Pressure for Stem-Cell Therapy Accomplishments

Global competition within the medical science field is well recognized.  In 2013, Japan’s Health Ministry cleared the way for the world’s first clinical trial with stem-cell s made using a separate technique from Shinya  Yamanaka, the Nobel Prize winner from KyotoUniversity.   And, Japan’s Prime Minister Shinzo Abe aims to cement his country’s leadership in the field of Stem-Cell therapy research.  He has pushed through bills that fast-track regulatory approval for cell-based products and set new research guidelines.

Regarding the research and paper submitted by Teruhiko Wakayama,  Japan’s Riken research center  (a government-funded organization) will continue an investigation  of the two studies published January 2014 in the journal, Nature, and will consider its options including retracting them from publication.

Still, the word is out.. There might be a faster and simpler method for making stem cells, and influencing stem-cell therapy.

Dr. Gill Research

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2 April 2014 at 22:38 - Comments

Eph-B4: An Improvement and Better Options for Lung Cancer Patients

PRESS RELEASE
February 23, 2014

Ask Dr. Gill about the most recent clinical trials avaialbleFor several years, Dr. Parkash Gill of the USCNorrisComprehensiveCancerCenter has proceeded with Phase I Clinical Trials with the new cancer fighting drug Eph-B4 made available to qualifying mesothelioma patients. With generous support from the Mesothelioma Research Foundation of America, the initial Phase I Trial Eph-B4 has been available to newly diagnosed patients who have not undergone any conventional lung cancer treatment options, as well as those patients who have exhausted all other treatment options such as surgery and chemotherapy.

The results of these recent clinical trials have truly been exciting as Dr. Gill reports that Eph-B4 is showing great promise as a solo treatment, or in conjunction with other drugs like Alimta, Cisplatin and Carboplatin.

The research of Dr. Gill, in conjunction with similar studies by other Oncologists, have improved the understanding among Primary Care physicians about the detection process, and given them better options to offer patients with lung cancer including mesothelioma.

Improvements for cancer patients

Early detection of lung cancer has improved with the use of Spiral CT scanners.  Computed tomography (CT) is an imaging procedure that uses special x-ray equipment to create a series of detailed pictures, or scans, of areas inside the body. It is also called computerized tomography and computerized axial tomography (CAT) scanning.   In cancer, CT may be used to help detect abnormal growths; to help diagnose tumors; to provide information about the extent, or stage, of disease; to help in guiding biopsy procedures or in planning treatment; to determine whether a cancer is responding to treatment; and to monitor for recurrence.  For people who do not have lung cancer but are at risk, the proper and early use of a CT scanner with annual inspections can reduce mortality rates in the US by 20%.

Eph-B4 as a Better Treatment

Treatments have also gotten better because we now understand two principles: a)molecular changes in lung cancer with very specific mutations; and b)medication (like Eph-B4) that is specific to addressing the treatment of only one cellular abnormality.

As Dr. Gill with the Mesothelioma Research Foundation of America continues the goal to make mesothelioma a disease of the past, our understanding of the human body immune system has also improved.    From this we have Eph-B4, an immune specific treatment that assists a patient with lung cancer to live longer with fewer side effects.

Our research has contributed to the evolution of mesothelioma cancer research over the last decade.  Collectively, researchers are producing a canonical story in which the range of research works has grown a consensus among recognized oncologists and Primary Care physicians of a “great” or “major” break through with the two principles mentioned above.  Basically, we can now identify subsets of cancer in a patient at the molecular level and bring a retardant treatment (immunity) to that cancer in those patients.  And this observation continues to this day to be repeated by many research projects.  More than ever before, researchers continue to identify specific cancer mutations and use similar drugs to shut down these cancers and improve patient survival.

The Future in Lung Cancer Research

The development of research in cancer resistance will be the next wave of understanding and will lead research teams into novel ways to overcome cancer resistance to treatments.  This will include discovery efforts through second and third generation cancer inhibitors; incorporation of other cancer targets that may be found; and possibly adding inhibitors that may change protein folding associated with molecular cancer mutation.  Each new discovery makes an opportunity to also create a specific, focused drug treatment.

Going forward with mesothelioma cancer research, our researchers will also begin defining those cancer mutations in which there is no antigen driver.  We will learn how to integrate targeted agents, how to sequence and / or combine them to inhibit multiple cancer growth signals.  Future research will also teach us how to do inhibitor agent integration so that the toxicity of the treatment is most effective and safe for the cancer patient.

Lung Cancer Early Detection Saves Lives

The cancer research industry and medical doctors practicing lung cancer treatment will become more proficient at explaining the benefits of the complex investigation associated with lung cancer screening tests.  Primary care physicians will become more knowledgeable and comfortable with their understanding of the new research about lung cancer.  Presentations about lung cancer screening and its benefits will help persons at risk of lung cancer to have less fear about the process and discover how screening saves lives; maybe their life.  While considering the costs and benefits of lung cancer screening, one must also balance the perspective with the knowledge of 160,000 persons who die each year from lung cancer, which many might be saved by choosing lung cancer screening.

Phase II Clinical Trials of Eph-B4 to Soon Begin

Dr. Gill has several mesothelioma cancer victims currently in the Phase I clinical trial using the Eph-B4 drug, and being treated at USCNorrisComprehensiveCancerCenter in Los Angeles.  The improved results these cancer patients are displaying are very encouraging to the USC Norris cancer research team.  Consequently, Dr. Gill has recently received permission from the FDA to enter into clinical trials for Phase II.  This study will proceed and include cancer patients with mesothelioma as well as pancreatic cancer.

Contact Dr. Gill for more information: (800) 909-6376 or www.mesorfa.org (ask Dr. Gill)

Reference:

  • Dr. Parkash S. Gill is a professor of Medicine and Pathology and leads the MesoRFA.org research team.
  • The Mesothelioma Research Foundation of America has a mission: fund research that will lead to the quickest cure for mesothelioma. Since 2001, the foundation has funded the Cancer Research Laboratory under the supervision of Dr. Gill at the USC/Norris Comprehensive Cancer Center in Los Angeles.  Dr. Gill (a board certified oncologist and hematologist) has received FDA approval to provide Clinical Trials for lung cancer patients using new treatment drugs with research 100% funded by the foundation.  We are all very excited at the possibilities of a more effective treatment over what presently is available for lung cancer victims.
23 February 2014 at 01:40 - Comments

Dr. Parkash Gill and Novel Therapeutic Targets (EphB4, Axk, GRP78) in Pancreatic Cancer

English: Gene expression pattern of the EPHB4 ...

Gene expression pattern of the EPHB4 gene

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.[1][2]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.[2][3]

APA/Hirshberg Symposium: Celebrating 10 Years of the Hirshberg Seed Grant THERAPY Novel Therapeutic Targets (EphB4, Axk, GRP78) in Pancreatic Cancer Dr. Parkash Gill.

  1. Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT (Jun 1994). “Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily”. J Biol Chem 269 (19): 14211–8. PMID 8188704.
  2.  Jump up to:a b “Entrez Gene: EPHB4 EPH receptor B4″.
  3. Jump up Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999). “Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development.”. Mol. Cell 4 (3): 403–14. doi:10.1016/S1097-2765(00)80342-1PMID 10518221.
15 January 2014 at 18:12 - Comments

Useful Mesothelioma Information To Know

Mesothelioma is a rare form tumor cancer.  It refers to the cancerous tumor which primarily involves the mesothelial cells of the human organs, usually abdominal organs or lungs. Since most mesothelioma cancer cases are unsuccessful, it is just important to know some mesothelioma information to make sure you are not afflicted with this threatening disease.

Pleural mesothelioma is the common type of mesothelioma disease . This mesothelioma cancer strikes the pleura which is the membrane between the lungs and the chest cavity.  A lubricated surface to prevent the lungs from chaffing against the chest walls is provided by the membrane.  So, a pleural mesothelioma attack is also known as lung cancer.

Another form of mesothelioma cancer that frequently occurs is called  peritoneal mesothelioma. This cancer afflicts the peritoneum membrane which  encloses the abdomen organs.  Although peritoneal mesothelioma does not  occur as commonly as Pleural mesothelioma, it does tends to be more threatening and invasive.  Therefore, this may result in a shorter life period for the patient.

Mesothelioma Information – Brief History

Where does mesothelioma come from?  This is the most common question asked by persons diagnosed with mesothelioma.  The most common short  answer: exposure to airborne asbestos particles.  When a person is diagnosed this disease,  the cancer’s onset is usually found to be related to a history of asbestos exposure. Asbestos is a mineral, mined and used for many decades as a main thermal insulation material.  Since the 1920′s, it has been widely known that asbestos is a carcinogen, which can cause cancer. Still, asbestos continued to be used in many products until the early part of 1970, and consequently is found currently in many buildings today.60,000 die of asbestos mesothelioma

A unique feature of various asbestos caused diseases is that they have a long latency period.  In other words, from the day of exposure to asbestos fibers and breathing the asbestos dust and the noticeable onset of the cancerous disease can take many years.  A common latency period for mesothelioma cancer can be 20 to 50 years, and sometimes more time.  Therefore, a person can be exposed to asbestos many years ago and only now begin to show the development and signs of mesothelioma.

Clinical Signs and Symptoms of Mesothelioma

With mesothelioma, the signs and symptoms for this cancer can be very general, and unfortunately doctors have misdiagnosed and often neglected and ignored the signs.  In many cases, the signs and symptoms for this cancer type arise between 2 and 3 months before the cancer is fully diagnosed.

Making decisions about what to do with mesothelioma cancer is greatly dependent upon which stage the tumor is at upon discovery.  When you have an early diagnosis of mesothelioma than surgical intervention can sometimes prolong life expectancy.  Depending on the patient’s physical condition and age, the option for surgery may not be possible.  In addition to the option for surgery, then chemotherapy and radiation treatment may be useful in the treatment of mesothelioma.  Finally, home care and pain reduction options are common alternatives and considerations during the later stages of mesothelioma cancer before death.

Where To Go After A Diagnosis with Mesothelioma?

When a person has been diagnosed with mesothelioma, it becomes most important to understand and know the medical treatment options available for the patient.  Always contact and ask questions with an oncologist, or at least your personal doctor so they can provide you with information about mesothelioma as well as some treatment options to choose from.

If you need to speak with an oncologist, Dr. Gill with the Mesothelioma Research Foundation of America welcomes your questions and will gladly provide answers for free.  Simply click on this link and use this contact form to send the doctor your concern.

11 April 2013 at 05:15 - Comments

Mesothelioma Cancer – The Latest News

Mesothelioma kills life-long criminal and infamous author

James Fogle stole his first car at the young age of 12 and set a course for the remainder of his life that would consist of an endless string of crimes.  James, who contracted mesothelioma, spent most of his life living in a prison, and eventually died living behind bars at the age of 75 in August, 2012 probably from the malignant mesothelioma he got while working as a pipe fitter.

Fogle described himself as a restless child born in a small town in Wisconsin and lived with an abusive father.  Early in his youth, he decided that stealing cars would be a form of escapism.  Consequently, James would spend much of his life as a youth in juvenile correctional facilities.  According to his autobiographies, it was in these facilities where he learned methods from other criminal detainees on how to pull off various crimes.  As he sustained his life path of criminal behavior, after serving time in jail as an adult and learning from fellow inmates, upon his release he began robbing drugstores.  James Fogle, all his life, was in and out of prison and seldom experienced freedom for more than a year between sentence terms.James Fogle dies of mesothelioma while living in prison

During one of his prison terms, he was trained to be a steam pipe fitter.  It is suspected that during this era of his life he was exposed to asbestos, which later led to his development of mesothelioma.  When one is  exposed to asbestos fibers, some of the fibers floating in the are you breath can become trapped in the lungs when inhaled, and this can cause the deadly diseases known as mesothelioma.  Mesothelioma lung cancer is caused by exposure to floating asbestos particles.  However, with mesothelioma there is usually a latency period of 20 to 50 years from the time of exposure before the development of symptoms can be recognized.

Mesothelioma diagnosis typically begins with a sufferer’s visit to the doctor complaining of chronic chest pain. This pain is caused as a result of a buildup of fluid inside the pleural space; this is called pleural effusion and is the most common presenting symptom of malignant mesothelioma.

Preliminary mesothelioma detection can be achieved through a chest imagery scan (CT scan, x-ray); however, mesothelioma is often misdiagnosed as viral pneumonia at this stage because of certain symptomatic similarities between the two. The only way to definitively verify a suspected case of malignant mesothelioma is through a biopsy.

Because of his mesothelioma cancer condition and toward the end of his life, James was required to use an oxygen tank to breathe.

Mesothelioma kills book writer

While James  only had a sixth-grade education, he became inspired by books he read during his prison time.  From his reading he developed his own writing style, and wrote 11 autobiographical novels while doing his time.   “Drugstore Cowboy,” is the story about drug addicts who teamed up to support their drug addictions by working together to  rob  pharmacies.  This was the only book he wrote that got published.  This novel was used to create a highly-regarded and  successful film by director Gus Van Sant.  The film was made in 1989 with Matt Dillon playing the lead role.  William Burroughs, one of the major faces of the Beat Generation, had a minor role in the movie, and lauded Fogle’s novel.

At the Monroe Correctional Complex in Monroe, Washington, James Fogle was serving out his 16-year sentence for  crimes committed when he died of mesothelioma cancer.

References:

http://www.nytimes.com/2012/08/30/us/james-fogle-author-of-drugstore-cowboy-dies-at-75.html

http://articles.latimes.com/2012/aug/26/local/la-me-james-fogle-20120826

http://seattletimes.com/html/obituaries/2018979541_cowboy24m.html

21 March 2013 at 22:51 - Comments

Mesothelioma Awareness Gets A Boost On Rare Disease Day 2013

Mesothelioma awareness fits the focus of  Rare Disease Day 2013

The fifth annual U.S. Rare Disease Day was held on February 28th.  Organized and supported by the National Organization for Rare Disorders (NORD), this event has been created to direct public attention on approximately 7,000 rare diseases that affect almost 30 million people in America.  And among the rare “orphaned” disorders is Mesothelioma, the  asbestos-related cancer disease which affects one-tenth of the American population.

Mesothelioma, NORD and Rare Disease DayOrphan disease status is assigned to any disease or disorder that fewer than 200,000 people in the United States.    Mesothelioma cancer, for example, has about 3,000 people in American that are diagnosed each year with the disease.   Rare Disease Day is an international advocacy day designated to raise public awareness of rare diseases, such as Mesothelioma,  and increase recognition globally with a concern solving rare disease effects.

According to NORD president and CEO, Peter Saltonsall, “There are nearly 30 million Americans—and millions more around the world—affected by rare diseases”

“Everyone knows someone with a rare disease. But, while many of these diseases are serious and lifelong, most have no treatment and many are not even being studied by researchers. This leaves patients and families without hope for a better future.”

Because mesothelioma is relative rare, as are other orphan diseases, managing this cancer and attempting to discover  appropriate treatment is sometimes overwhelming to the patient and their family.  And based on government statistics, orphan diseases are serious or life-threatening to  85-90 percent of patients, and still as few as 200 of theses diseases  like mesothelioma have any effective treatments currently.

Mesothelioma Cancer and the National Organization for Rare Disorders

This years conference theme for 2013 is global in focus, called  “Rare Disorders Without Borders.”   The day will have special significance for the United States since this year 2013 is the 30th anniversary of the congressional Orphan Drug Act.  Therefore, there are additional incentives that should encourage U.S. companies to develop treatments for rare diseases, as well as for  N.O.R.D. which was established in 1983 by advocates of patients with rare disorders like mesothelioma cancer.

N.O.R.D. set the 2013 program for Rare Disease Day to include activities in the U.S. that place a spotlight on awareness events at many  State Houses, a Rare Disease Research Hall of Fame, a Handprints Across America photo gallery, and an event at the National Institutes of Health (NIH) in Bethesda, MD.

Even after the passing of this special day, we still need your support and advocacy, so you still can get more information about Rare Disease Day activities for the United States at: www.rarediseaseday.us.  And additional information about global activities can be found at:  www.rarediseaseday.org.

MESOTHELIOMA DIAGNOSIS

Mesothelioma diagnosis typically begins with a sufferer’s visit to the doctor complaining of chronic chest pain. This pain is caused as a result of a buildup of fluid inside the pleural space; this is called pleural effusion and is the most common presenting symptom of malignant mesothelioma.malignant mesothelioma xray

Preliminary mesothelioma detection can be achieved through a chest imagery scan (CT scan, x-ray); however, mesothelioma is often misdiagnosed as viral pneumonia at this stage because of certain symptomatic similarities between the two. The only way to definitively verify a suspected case of malignant mesothelioma is through a biopsy.

A biopsy is a relatively minor procedure (dependent on the location of the tumor) during which a small section of suspect tissue is removed. The removed section is examined by a histopathologist, an expert in the study of diseased tissue. Histopathological examination can confirm a case of malignant mesothelioma while also typing and staging it. Understanding the type and stage can help doctors suggest the best of treatment.

You can also have your questions about malignant mesothelioma and clinical trials for new cures, answered for free by Dr. Gill at the Mesothelioma Research Foundation of America by clicking here: Ask Dr. Gill

12 March 2013 at 10:51 - Comments

Vacuum Cleaner Theft Sparks Asbestos Fears

Asbestos Fears Sparked By Vacuum Cleaner Theft

Police from Great Britain  are asking the public to help find a stolen industrial vacuum cleaner which was used to suck up and remove asbestos.  According to BBC reports, thieves broke into a construction site under renovation over the weekend in the town of Carlisle, northern England.  After moving five vacuum cleaners into another room, the robbers chose to steal a yellow Numatic cleaner.  Unfortunately,  anyone coming in contact with that cleaner will now face serious health risks  and is advised not to touch the unit because it contains asbestos.  Just three years previously, a  situation just like this occurred when burglars stole a batch of industrial vacuums from Redcar & Cleveland College in Northeast England.  According to the BBC, the police responded by releasing a warning to the public that told them not to purchase the cleaners if they were offered them.

Asbestos is Cause for Extreme CautionAsbestos is Cause for Extreme Caution Danger

When it comes to asbestos, the cause for extreme caution is warranted. According to the U.S. National Cancer Institute, there is no recognized safe level of asbestos exposure.  Inhalation of the fibrous mineral causes serious illnesses, including asbestosis, cancers of the lungs and other organs, and mesothelioma.  Asbestos is present in many older buildings in the United Kingdom and the United States.  Versatile, cheap, and flame-retardant, the fibrous mineral was used extensively in building materials until about 1980, when the dangers of inhaling the material became widely known.  Because asbestos-related diseases such as mesothelioma take decades to develop, thousands of people were exposed to the material while working on job sites.  Have you been diagnosed with mesothelioma or any other asbestos-related condition?  Do you believe you were exposed to asbestos at a job site?  Then you may be interested in having your questions about asbestos exposure and the possibility of having mesothelioma answered by Dr. Gill, here at the Mesothelioma Research Foundation of America

 

 

7 March 2013 at 22:51 - Comments

How Mesothelioma Might Impact Long Term Health

Mesothelioma Diagnosis

While it might seem that a diagnosis is the most important part of mesothelioma and handling your health, this is far from the case. The diagnosis is merely the starting point from which you need to begin treatment. And though your health might be something you consider to be priceless, it is also something which can be very expensive when it comes to managing mesothelioma. This is why those with mesothelioma seek legal restitution for their injuries. Though your initial diagnosis can be traumatic, the bills which come from your long term care can be catastrophic without the financial help you deserve from an employer.

Mesothelioma is a Cancer

malignant mesothelioma xrayAs one of the rarest forms of cancer, mesothelioma is a condition which impacts not only the lungs, but the entire body as well. A cancer is a condition in which cells are damaged at the DNA level and then when they replicate, the cells are then damaged, causing pain, illness, and tumors. If the cells can be destroyed via radiation, chemotherapy, or other treatments, the cancer can be cured. But as mesothelioma tends to spread in the body before it is detected, it can be difficult to cure this cancer without using a combination of treatments, all of which may not completely remove the cancer from the body.

Radiation and Chemotherapy for Mesothelioma

In order to stop the spread of mesothelioma in the body, most doctors will prescribe radiation and chemotherapy treatments. While these can be wildly successful, they can also be very difficult to manage in some patients. As every patient is different and every cancer is different, you may find that your mesothelioma doesn’t respond to one treatment, but does respond to another – and of course that is the treatment which is not covered by your insurance policy. Each radiation and chemotherapy treatment can cost thousands of dollars and they need to be given regularly in order to provide the results you and your mesothelioma need.

Surgery and Combination Treatments

Sometimes, the only thing which can be done to help mesothelioma is to remove the tumors which are spreading in the body. This is painful, extensive, and possibly even debilitating if there are enough tumors which need to be removed. With the proper financial compensation for mesothelioma, you will be able to not only pay for the surgeries and their related costs, but you will also be able to pay for the pre- and post- care needs. You will be able to also have follow-up surgeries if the mesothelioma proves to be difficult to manage.

More Mesothelioma Articles

28 January 2013 at 16:19 - Comments

What Causes Mesothelioma?

mesothelioma lung cancerMesothelioma cancer affects many former workers who were employed at factory, military, shipyard and construction projects.  Mesothelioma has been proven to be primarily caused by exposure to asbestos, even though there are other aggravating factors that also worsen a mesothelioma condition.

What is Mesothelioma?

Mesothelioma are tumors that affect the lining surrounding many of the body’s internal organs.  The tumors can cause symptoms such as severe chest pain, fatigue, anemia, low blood sugar levels, lung collapse, and shortness of breath.  Mesothelioma can also spread as tumors all over the body except for the brain, the skeletal system and the adrenal glands.  Mesothelioma symptoms will usually have a long latency time before they manifest as much as 15 to 30 years.  The cancer is difficult to treat or prevent because in most cases it is not diagnosed until decades after the patient had their initial exposure to asbestos which caused the mesothelioma tumors.

How Does Asbestos Exposure Occur?

Asbestos is the common word given to a wide range of minerals that have been used for many years of history being most recently processed for use in several industrial applications.  Asbestos is efficient as an inexpensive insulator which made it popular for use in the construction of homes created before the 1970s.  It was also applied a lot to military ships during World War II.   Asbestos in its raw mineral form has small particles which can easily become airborne, and when they are inhaled can cause a great risk to health.   Once the asbestos particles get inside the body, their abrasive dust fragments lead to the development of mesothelioma tumor cancer.  Unfortunately, there have been shipyard workers and factory people that have been exposed to the inhalation of asbestos particles long before the correlation between asbestos and mesothelioma became recognized.

What Can Be Done About Mesothelioma

Contemporary construction workers involved with the renovation of older buildings are much at risk for exposure to asbestos which induces mesothelioma.  Because mesothelioma has many symptoms that are similar to many other common diseases, its early diagnosis is very complicated to do.  A detailed review of a patient’s medical history and occupational experience is necessary to obtain an accurate diagnosis of mesothelioma.  A thorough patient medical history review is usually followed by thorough physical examinations that include chest X-rays, lung function tests and CT scans or MRIs.

Mesothelioma can be resistant to surgery, so there are few other treatments that might provide some form of cancer relief.  Chemotherapy is a common treatment administered as a recourse, and immunotherapy treatments have shown promise to provide various results of success.

More Mesothelioma Articles

28 January 2013 at 16:00 - Comments
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