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MesoRFA Information and Press Releases

Working on a cure for Mesothelioma

Possible New Treatment for Mesothelioma with MicroRNA Research

Today’s cancer cure researcher will frequently dig deep into the genetic makeup of the cancer disease to understand how it grows.  While in search for the most effective treatment to cure lung cancer and mesothelioma, and by genetically figuring that out, the researcher can stop the aggressive cancers by halting its growth.  Currently, Oncologists believe that a pair of microRNAs should be focused on for suppressing tumor growth in lung cancer.microRNA genetic research mesothelioma

microRNAs, or miRNAs, are tiny molecules found within cells that serve a function in primary biological processes.  These processes include organ development, fat metabolism, and cell proliferation.  A person remains healthy when miRNAs are functioning properly.  And, miRNAs can inhibit tumor growth when used as a therapeutic agent.

While miRFAs let-7 and miR-34 are known to be effective individually at stopping cancer growth, researchers at the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) found that by combining these two molecules the pair are even more effective.

MicroRNA and Lung Cancer

Specifically, the miRNAs were unleashed on cancer pathways RAS and p53, two oncogenes, genes that have the potential to transform a cell into a cancer cell, known to lead to the aggressive growth of non-small cell lung cancer (NSCLC).  The resulting two-molecule agent was found to be safe and effective in a lung cancer mouse model and demonstrated efficacy showing survival advantage.

According to one of the authors, Frank Slack, PhD (Director of the Institute for RNA Medicine in BIDMC):   “We know that miRNAs target many oncogenes.  We, therefore, hypothesized that a combination of two miRNAs could similarly offset resistance.  We have performed these timely in vivo studies using a liposomal microRNA delivery agent already in clinical trials, which could accelerate the translation of this combinatorial miRNA therapeutic approach into the clinic.”

Dr. Slack also said that currently there are no approved drugs that are effective for patients with RAS and p53 mutations. He mentioned reports that the K-RAS mutation is found in 25 percent of NSCLC patients while 50 percent are affected by the p53 mutation.

Pleural Mesothelioma

Pleural mesothelioma, an asbestos-caused cancer equally as aggressive as NSCLC, is diagnosed in close to 3,000 Americans each year.  And while microRNA research is focused on lung cancer, every new breakthrough in lung cancer research also brings new hope to patients with mesothelioma cancer.

The study was published in the Sept. 1 issue of Oncogene.

17 October 2014 at 10:21 - Comments

New Cancer Treatments Using T-Cell Genetically Modified Therapy

Incredible results within some clinical trials are showing up for cancer treatments where genetically modify patients’ blood cells are created to target specific cancer disease.

Based on two clinical trials, nearly 90% of patients had their leukemia disappear after receiving an experimental therapy using genetically modified  CAR T-cells.   These trials were sponsored sponsored by Novartis AG NOVN.VX -0.72% of Switzerland and Seattle-based biotech Juno Therapeutics Inc.  The results were published in December and February of 2014.

Both trials included just a few patients: 22 children in the Novartis trial and 16 adults in the Juno trial.  All patients had a common childhood cancer, acute lymphoblastic leukemia, and these patients each had exhausted standard cancer treatments.

According to Dr. Daniel DeAngelo: “CAR T-cells are probably one of the most exciting concepts and fields to come out in cancer in a very, very long time.”  Dr. DeAngelo is a Boston-based hematologist and associate professor of medicine at Harvard Medical School.  He was is not involved in either of the clinical trials.

In an interview with The Wall Street Journal, Dr. Usman Azam said “I think that a cure for cancers such as leukemia and lymphoma through a CAR technology is plausible.  Oour job is to get this into patients as soon as we feasibly can.”

Dr. Azam is the leader of cell and gene therapies at Novartis, and also heads the new unit Novartis created partly to speed the therapies’ time to market.

T-Cell CAR therapies combine the methods of genetic tweaking and “immunotherapy,” which uses the patient’s immune system to fight disease. The genetic part of the method involves extracting disease-fighting white blood cells called T-cells from a patient’s blood. The T-cells are then genetically modified, grown in a laboratory dish for around a short period of time, and then injected back into the patient.

Genetically Modified T-Cell cancer therapy

The laboratory dish process is where T-cells are combined with a disabled virus.  The virus enables the T-cells to produce Chimeric Antigen Receptors (CARs) that can recognize and target malignant proteins on the surface of cancer cells.

Novartis is funding the development of their treatment in partnership with the University of Pennsylvania, while Juno’s funding is in partnership with teams at Memorial Sloan-Kettering Cancer Center in New York, Seattle Children’s Hospital and Seattle’s Fred Hutchinson Cancer Research Center.

For patients seeking potential solutions to their cancer, knowing who is developing new treatments brings them to the opportunity to participate in Clinical Trials to get early results to cancer cure.  Therefore, while Novartis and Juno are ahead in the race to bring Genetically Modified T-Cell cancer therapy to the mass of cancer patients, there is also others developing similar therapy methods including  Pfizer Inc., PFE -0.04% Kite Pharma Inc. KITE -3.75% and Celgene Corp. CELG -1.14%  (in collaboration with Bluebird Bio Inc. BLUE +1.43% ).

Genetically modified T-Cell therapy deploying CARs is very new;  so there are unresolved questions about the method of using this kind of therapy.

How Long Does T-Cell CAR Treatments Last Keeping Cancer In Remission?

Because the current clinical trials treated only a small number of patients, as well as many of those patients whose cancer went into remission after the T-Cell CAR treatment where then eligible for subsequent stem-cell transplants (which can also increase survival), there is no absolute evidence and history to yet determine the longevity this treatment produces.

Additionally, there is a potential dangerous side effect for some patients called “cytokine-release syndrome,” an immune response while the therapy is working, can cause a sharp drop in blood pressure and surge in the patient’s  heart rate.

In March 2014, a Juno-backed Sloan-Kettering trial was held over the deaths of two patients.  That has caused a temporary halt in the T-Cell CAR study because of worries about the dangerous immune response and two deaths.

But, the clinical trial is again recruiting patients giving those with very advanced leukemia fewer modified cells, and excluding those patients with a risk of heart failure.

Can T-Cell CAR Treatments Be Created At Affordable Cost?

Due to the genetic engineering involved with T-Cell CAR therapy which is very complex to manufacture with each laboratory batch being a unique personalized treatment customized to a cancer patient’s own blood cells, the inability to mass-produce T-Cell CAR therapy questions the implication about how much companies will charge for the therapy.

Dr. Malcolm Brenner, director of the Center for Cell and Gene Therapy at the Texas Children’s Hospital in Houston, reminds us that “What we’re talking about here is a single, very expensive therapy that’s used once for a specific patient and is not generalizable.”

While Citigroup believes T-Cell CAR therapy could cost in excess of $500,000 per patient, which it notes is roughly the same cost for a stem cell transplant, most analysts still think it is too soon to approximate the future revenue or price for this therapy.

Again, Dr. DeAngelo clarifies:  “This technology needs to be widely developed and accessible to patients; if the cost is going to be a hindrance, it’s going to be a really sad day.”

For these reasons and more,  Pfizer is taking a different approach to this treatment with a focus on managing scalability and cost.  “We would like to take it to the next level, where CAR therapies become a more standardized, highly controlled treatment,” said Mikael Dolsten, Pfizer’s head of global research and development.

Pfizer wants to develop a generic T-Cell CAR therapy for use in any patient, potentially lowering its cost.  So, Pfizer is collaborating with French biotech Cellectis SA, ALCLS.FR +1.89%  on T-Cell CAR research that is currently preclinical.

Even if  T-Cell CAR treatments being developed might justify “outrageous” prices, it is probably that health-care payers as well as patients might object and fight back.  International director of health-care research at Société Générale, Stephen McGarry, asks:  “When you look at the initial data with the Novartis therapy, you’re getting cures in some kids—what do you charge for that?”

So, the drug companies and biotechs must overcome big hurdles to get their T-Cell CAR therapies into hospitals, and manage their potential cost.  And the biggest challenge may be the cost of the therapies.

15 October 2014 at 10:27 - Comments

Computed Tomography Screening for Mesothelioma Finds Asbestos-Related Lung Disease, According to Surviving Mesothelioma

Recent Tomography Research for Mesothelioma

The original study is published in the Journal of Computer Assisted Tomography (Carrillo, MC, et al, Low-Dose Computed Tomography (LDCT) in Workers Previously Exposed to Asbestos: Detection of parenchymal Lung Disease, July-August, 2013, Journal of Computer Assisted Tomography, pp. 626-630).

Recent research study reports that a lower dose of the same technology often used to diagnose mesothelioma may be able to help identify other asbestos-related lung diseases in people at risk for the deadly cancer.Tomography and Mesothelioma

Tomography in Canada for Mesothelioma

A study in Canada states that it tested the value of Low-Dose Computed Tomography (LDCT) for lung disease in asbestos-exposed workers.  The individuals were being screened for lung cancer or mesothelioma.  The Canadian research study focused on 315 baseline LDCT examinations of the chests of participants with at least 20 years of exposure to asbestos. Also included in the analysis were people who were found to have pleural plaques on X-ray (these are areas of calcification on the lung lining caused by asbestos).

The average age of the study participants was just under 62. All had been exposed to asbestos in an occupational setting for an average of 26.9 years. Forty-four percent of participants (140 people) had what were called parenchymal findings, or evidence of abnormalities in their lung tissue. Although such parenchymal findings do not necessarily indicate the presence of lung cancer or mesothelioma, they can be early evidence of a developing problem.

Study participants with parenchymal findings were like patients with mesothelioma in that they tended to be older (average age of 65.3) and have longer-than-average asbestos exposure (average of 29.73 years).  While many participants were also smokers, there was no statistical difference in parenchymal findings between those who smoked and those who did not.

The study concluded that LDCT can be a valuable way to detect early signs of lung disease in people who have no symptoms but are considered at high risk. Like lung cancer and mesothelioma, parenchymal lung diseases are most treatable when detected early. Unfortunately, mesothelioma is almost never found early because it tends not to produce any noticeable symptoms until it is in its later stages.

Because asbestos is the only known cause of mesothelioma, some have suggested the LDCT should be a regular part of health maintenance for all asbestos workers. The current study is further evidence of the value of the technology. Although mesothelioma is often treatment-resistant, it is more responsive to therapy before it has spread beyond the pleural lining and invaded the lungs or lymph nodes.

More Mesothelioma Cancer Press Releases

27 June 2014 at 11:15 - Comments

New Drug Targets Cancer Caused By Asbestos

May 26, 2014

Mesothelioma lung cancer can come to those persons who loved, and simply hugged their parent who worked around asbestos.  For example, now at age 45, Heather Von St. James recalls her father working as a building demolition employee around materials containing asbestos.  He would return home each day thoroughly covered by dirt and dust. She remembers how much she enjoyed hugging her father each night.mesothelioma-studies

By age 36, Heather was diagnosed with mesothelioma, the deadly yet to be cured cancer connected with exposure to asbestos particles.  Mesothelioma can take decades to develop and it often kills within months after symptoms appear. Heather was a new mother to a 3-month-old daughter, and she was told her only chance to live was by having a lung removed.

In 2013, more than 107,000 people died worldwide from mesothelioma.  However, Heather opted for the surgery instead, and removed the disease in time to stay alive.   According to Ms. St. James, “There’s a lot of people who don’t.”

Fortunately for other people with mesothelioma, or those that will discover they have the deadly disease, a new wave of drugs developed and being tested are giving new hope that mesothelioma cancer may be slowed or stopped.  Drug researchers, like Verastem Inc. (VSTM), GlaxoSmithKline Plc (GSK), and Dr. Parkash Gill of the USC Norris Comprehensive Cancer Center have announced that they are testing new cancer fighting drugs.

According to Dean Fennell, a lead researcher doing a trial study with a new drug by Verastem:

“[Mesothelioma] is not a curable cancer; it’s not a disease that can be wiped out completely by surgery as you see with lung cancer. Finding ways to stop that process or slow it down can have big implications for patient survival.”

Unlike lung cancers, Mesothelioma affects the cell tissues that cover the lungs.  It can also affect the tissues around the heart and abdominal organs.  Like all cancers, mesothelioma is treated by doctors with cutting the cancer tissue out, or irradiating it, but both methods sometimes have dangerous side effects.

New Drugs Offer New Hope to Replace Old Treatments

Verastem (based out of Cambridge, Massachusetts) has developed a drug (VS-6063) that is now in late-stage human testing. Consecutively, Glaxo (based out of London) has a compound that is being tried in combination with another product in an early-stage study. The drugs from these two companies each target an enzyme involved in cell movement that permits the cancer to spread.

The enzyme is a key marker of aggressive cancers and is overabundant in many tumors that spread quickly. Also, patients with an inactive gene called Neurofibromatosis 2 (NF2) respond well to the test drugs being developed where nearly half of mesothelioma patients have inactive NF2s.

In the U.S. and Europe, the VS-6063 treatment has been granted orphan drug status.  This means that Verastem with their VS-6063 product is given seven (7) years of exclusive marketing.  A Bloomberg report states that according to four (4) analysts, the VS-6063 drug could possibly generate $450 million in sales by 2019 if the product is cleared for public use.

Earliest Stage

Defactinib is the medicine that targets early stage cancer stem cells.  These are considered to be theorigin of the cancer and frequently are resistant to existing therapies.   The cancer stem cells for mesothelioma are known to be particularly resistant to chemotherapy.

Now, Mr. Dean Fennell does not have an economic connection with Verastem, nor is he a paid consultant to the company.  And yet, Mr. Fennell (who is chairman of thoracic medical oncology at the University of Leicester in England) stated during an interview:

“The hope is we can suppress the cancer in such a way that it becomes a more chronic disease, rather than have a disease that’s going to progress relentlessly and kill the patient”

Verastem with a market value of about $215 million is developing the drug assisted by several renowned pharmaceutical companies providing guidance. The development team includes former Genzyme Corp. CEO Henri Termeer; Human Genome Project leader Eric Lander; and Phillip Sharp, a Nobel laureate at Biogen Idec Inc.

Other Drug Combinations

Under a license from Pfizer Inc., AstraZeneca Plc of London is testing a drug called tremelimumab, on mesothelioma in a mid-stage trial. The treatment works differently from the other developmental drugs in that it helps the patient’s immune system to recognize and kill cancer cells.  According to

Carolyn Buser-Doepner (VP for tumor signaling at Glaxo, the U.K.’s biggest drugmaker), there are plans to combine a new drug GSK2256098 with some other medicines to potentially make cancer treatments more effective.  In one early-stage trial, it will be paired up with Glaxo’s Mekinist, which is approved for melanoma.  She said, “The pre-clinical data are very encouraging. We’re very excited about it.”

Boehringer’s Drug

A fourth drug, nintedanib from Germany’s Boehringer Ingelheim GmbH, is in early-stage testing for mesothelioma, according to a spokesman. Unlike the previous mentioned medicines, this one works by targeting proteins directly related to the formation of blood vessels that feed tumors.

According to the director of research at the British Lung Foundation, Noel Snell, the kind of research studies most likely to yield improvements in cancer care are those that investigate the nature of the disease itself.  Still, treatments being tested today on mesothelioma are most encouraging.

Snell said in a statement:

“It is shameful that this kind of fundamental research remains so drastically underfunded, and that the number of trials available for mesothelioma patients is still dwarfed so dramatically by the number available to other cancer patients.”

Dr. Gill and EphB4 Treatment

For several years, Dr. Parkash Gill of the USC Norris Comprehensive Cancer Center has proceeded with Phase I Clinical Trials with the new cancer fighting drug Eph-B4 made available to qualifying mesothelioma patients. With generous support from the Mesothelioma Research
Foundation of America
, the initial Phase I Trial Eph-B4 has been available to newly diagnosed patients who have not Ask Dr. Gill about the most recent clinical trials avaialbleundergone any conventional lung cancer treatment options, as well as those patients who have exhausted all other treatment options such as surgery and chemotherapy.

The results of these recent clinical trials have truly been exciting as Dr. Gill reports that Eph-B4 is showing great promise as a solo treatment, or in conjunction with other drugs like Alimta, Cisplatin and Carboplatin.

The research of Dr. Gill, in conjunction with similar studies by other Oncologists, have improved the understanding among Primary Care physicians about the detection process, and given them better options to offer patients with lung cancer including mesothelioma.

Eph-B4 as a Better Treatment

Treatments have also gotten better because we now understand two principles: a)molecular changes in lung cancer with very specific mutations; and b)medication (like Eph-B4) that is specific to addressing the treatment of only one cellular abnormality.

As Dr. Gill with the Mesothelioma Research Foundation of America continues the goal to make mesothelioma a disease of the past, our understanding of the human body immune system has also improved.    From this we have Eph-B4, an immune specific treatment that assists a patient with lung cancer to live longer with fewer side effects.

His studies have contributed to the evolution of mesothelioma cancer research over the last decade.  Collectively, researchers are producing a canonical story in which the range of research works has grown a consensus among recognized oncologists and Primary Care physicians of a “great” or “major” break through with the two principles mentioned above.  Basically, we can now identify subsets of cancer in a patient at the molecular level and bring a retardant treatment (immunity) to that cancer in those patients.  And this observation continues to this day to be repeated by many research projects.  More than ever before, researchers continue to identify specific cancer mutations and use similar drugs to shut down these cancers and improve patient survival.

Asbestos: The Miracle Fiber That Kills

Asbestos was named the “miracle fiber,” but has become the topic and issue of many lawsuits claiming losses as well as damages from illness caused by asbestos products.  It was commonly used in building materials such as insulation for years because it was cheap, abundant and heat-resistant.

Many countries have banned asbestos mining.  However, the World Health Organization estimates that as many as 125 million people worldwide continue to be exposed to asbestos either at work or in their homes because it continues to be mined and made into  products from in RussiaChina and India.

Unfortunately, mesothelioma cancer can lay dormant for as long as 50 years before spreading, which explains why rates have risen long after many countries have banned the asbestos.

New cases of mesothelioma cancer in the United Kingdom, where asbestos was restricted starting in the 1980s and outlawed fully in 2006, were 2,125 in 2012.  These numbers are expected to peak in 2015.  In the United States, the number of new cancer cases has been stable, hovering around 3,000 per year since 2000.  This stability was expected because of extensive efforts put into public education.  Still, a complete ban of Asbestos in the U.S. was overturned in the courts.  One of the world’s largest asbestos exporters, Canada, closed its remaining mines in 2011.

An Asian Asbestos Mesothelioma Cancer ‘Tsunami’

In Japan, asbestos was banned in 2006, the Japanese government pays the full cost of treatment for related illnesses, and rate of new cases of cancer are predicted to continue rising until 2027.  The director of a World Health Organization occupational health group, Ken Takahashi, has warned Asian governments to prepare themselves for an “asbestos tsunami.”

Again, Dean Fennell reminds us:

 “In the early ’70s, this was an incredibly rare disease. Now my clinic is full of patients with mesothelioma. Because the rates are increasing, we have a real need now to identify effective treatment.”

A cure for mesothelioma can not be found fast enough.  Still, there are survivors like Heather Von St. James, who breaths with great effort during Minnesota winters with her one remaining lung, and she volunteers her time to be a coach to other mesothelioma patients.   By her personal experience with mesothelioma, she wants other victims of mesothelioma to understand:

 “If they can keep it under control,
that’s the first hope.”

 

26 June 2014 at 17:31 - Comments

Second Round of Chemotherapy May Not Help

According to a study by Turkish researchers, a second round of chemotherapy may not do much good for mesothelioma patients whose cancer returns after first-line treatment.

Chemotherapy CRS-207 mesothelioma vaccinationTheir findings are based on an analysis of 51 pleural mesothelioma patients from a Turkish hospital. All patients in the study were initially treated with chemotherapy, the standard first-line treatment for mesothelioma. But, when their mesothelioma tumors began to grow again several months later, some patients were treated with second-line chemotherapy (SLCT) while others had best supportive care (BSC), which includes symptom management only.

Chemotherapy Standard Is Tough

While chemotherapy is a standard first-line treatment for mesothelioma, an aggressive cancer of the mesothelial membranes, there is disagreement within the medical community as to whether or not second-line chemotherapy is effective. While it can sometimes slow the progression of mesothelioma, chemotherapy is also hard on the body and causes a range of dangerous side effects. For this reason, only the healthiest patients are even considered candidates for second-line chemotherapy.

Chemotherapy Survival Rates

In the Turkish study, patients who had chemotherapy as both a first- and second-line treatment had a median overall survival of 20.3 months. These patients had a median survival of 5.9 months after the end of their first-line chemotherapy. Patients who had only BSC when their mesothelioma began to grow again had a median overall survival of 14.7 months. The median overall survival for these patients from the end of their first-line chemotherapy treatment was 4.7 months.

While the figures seem to show that the second-line chemotherapy patients had better outcomes than those receiving BSC, the authors of the study say the differences between the two are not statistically significant. In addition, the fact that second-line chemotherapy is usually reserved for select patients may also contribute to the apparent skew of the results. They conclude, Our results do not support the proposal that second-line chemotherapy could be effective in patients with malignant pleural mesothelioma.”

While such studies can help guide mesothelioma treatment planning, treatment decisions are made on a case-by-case basis, based on a range of criteria. The original study appears in the Asian Pacific Journal for Cancer Prevention. (Mutlu, H, et al,
Secondline chemotherapy versus best supportive care in patients with malignant pleural mesothelioma: a retrospective study
2013
Asian Pacific Journal of Cancer Prevention
pp. 3887-3889
http://www.apocpcontrol.org/page/apjcp_issues_view.php?no=4654&gubun=p&s_search=mesothelioma&s_paper_vol=14&s_number33=6

4 April 2014 at 11:03 - Comments

No Short Cut to Accomplishments with Stem-Cell Therapy: Research Studies Might Get Retracted

Immunotherapy cancer stem-cell

Some recent research that specified a faster and simpler method for making stem-cell s just might get retracted because one of the two scientists involved in the research project has expressed doubts about the premises regarding their experiments.

It was Teruhiko Wakayama, a researcher at the University of Yamanashi, Japan, who stated he was no longer certain about the premise of the data he used.  During an interview with Japan’s largest international news service, NHK World, Mr. Wakyama said his research studies should be withdrawn from review.  His comments with the NHK news service emphasize the peer pressure that medical researchers experience with Japan’s push into stem-cell science subsequent to the Nobel Prize won by Shinya Yamanaka from KyotoUniversity in 2012.

Early Stem-Cell Therapy Developments

Basically, during an embryo’s early stages of development, stem cells are pluripotent, which mean they can become any type of tissue in a patient’s body.   As the embryo continues to develop, the stem-cell s begin to specialize by differentiation into units for the body’s different tissue structures.

There are currently several ways to regenerate pluripotent stem cells, including one method that uses embryos and another method that reprograms matured stem cells by inserting genes.

However, the controversial studies submitted by Mr. Wakyama discovered that ordinary cells taken from newborn mice could be transformed into stem-cell s without adding genes.   Instead, researchers (led by Haruko Obokata at the RikenCenter for Developmental Biology) shocked the cells with a dose of “sublethal stress” like mechanical force to trigger the transformation into stem-cell s.

According to Nissim Benvenisty, director of the stem-cell therapy laboratory at HebrewUniversity in Jerusalem:

“The study surprised me when it came out because it contradicted the common sense that we have acquired so far in the field.  At the same time, this is the beauty of the scientific world, in which editors allow publication of papers that contradict common sense to allow novel data to be discussed and understood.”

Global Pressure for Stem-Cell Therapy Accomplishments

Global competition within the medical science field is well recognized.  In 2013, Japan’s Health Ministry cleared the way for the world’s first clinical trial with stem-cell s made using a separate technique from Shinya  Yamanaka, the Nobel Prize winner from KyotoUniversity.   And, Japan’s Prime Minister Shinzo Abe aims to cement his country’s leadership in the field of Stem-Cell therapy research.  He has pushed through bills that fast-track regulatory approval for cell-based products and set new research guidelines.

Regarding the research and paper submitted by Teruhiko Wakayama,  Japan’s Riken research center  (a government-funded organization) will continue an investigation  of the two studies published January 2014 in the journal, Nature, and will consider its options including retracting them from publication.

Still, the word is out.. There might be a faster and simpler method for making stem cells, and influencing stem-cell therapy.

Dr. Gill Research

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2 April 2014 at 22:38 - Comments

Eph-B4: An Improvement and Better Options for Lung Cancer Patients

PRESS RELEASE
February 23, 2014

Ask Dr. Gill about the most recent clinical trials avaialbleFor several years, Dr. Parkash Gill of the USCNorrisComprehensiveCancerCenter has proceeded with Phase I Clinical Trials with the new cancer fighting drug Eph-B4 made available to qualifying mesothelioma patients. With generous support from the Mesothelioma Research Foundation of America, the initial Phase I Trial Eph-B4 has been available to newly diagnosed patients who have not undergone any conventional lung cancer treatment options, as well as those patients who have exhausted all other treatment options such as surgery and chemotherapy.

The results of these recent clinical trials have truly been exciting as Dr. Gill reports that Eph-B4 is showing great promise as a solo treatment, or in conjunction with other drugs like Alimta, Cisplatin and Carboplatin.

The research of Dr. Gill, in conjunction with similar studies by other Oncologists, have improved the understanding among Primary Care physicians about the detection process, and given them better options to offer patients with lung cancer including mesothelioma.

Improvements for cancer patients

Early detection of lung cancer has improved with the use of Spiral CT scanners.  Computed tomography (CT) is an imaging procedure that uses special x-ray equipment to create a series of detailed pictures, or scans, of areas inside the body. It is also called computerized tomography and computerized axial tomography (CAT) scanning.   In cancer, CT may be used to help detect abnormal growths; to help diagnose tumors; to provide information about the extent, or stage, of disease; to help in guiding biopsy procedures or in planning treatment; to determine whether a cancer is responding to treatment; and to monitor for recurrence.  For people who do not have lung cancer but are at risk, the proper and early use of a CT scanner with annual inspections can reduce mortality rates in the US by 20%.

Eph-B4 as a Better Treatment

Treatments have also gotten better because we now understand two principles: a)molecular changes in lung cancer with very specific mutations; and b)medication (like Eph-B4) that is specific to addressing the treatment of only one cellular abnormality.

As Dr. Gill with the Mesothelioma Research Foundation of America continues the goal to make mesothelioma a disease of the past, our understanding of the human body immune system has also improved.    From this we have Eph-B4, an immune specific treatment that assists a patient with lung cancer to live longer with fewer side effects.

Our research has contributed to the evolution of mesothelioma cancer research over the last decade.  Collectively, researchers are producing a canonical story in which the range of research works has grown a consensus among recognized oncologists and Primary Care physicians of a “great” or “major” break through with the two principles mentioned above.  Basically, we can now identify subsets of cancer in a patient at the molecular level and bring a retardant treatment (immunity) to that cancer in those patients.  And this observation continues to this day to be repeated by many research projects.  More than ever before, researchers continue to identify specific cancer mutations and use similar drugs to shut down these cancers and improve patient survival.

The Future in Lung Cancer Research

The development of research in cancer resistance will be the next wave of understanding and will lead research teams into novel ways to overcome cancer resistance to treatments.  This will include discovery efforts through second and third generation cancer inhibitors; incorporation of other cancer targets that may be found; and possibly adding inhibitors that may change protein folding associated with molecular cancer mutation.  Each new discovery makes an opportunity to also create a specific, focused drug treatment.

Going forward with mesothelioma cancer research, our researchers will also begin defining those cancer mutations in which there is no antigen driver.  We will learn how to integrate targeted agents, how to sequence and / or combine them to inhibit multiple cancer growth signals.  Future research will also teach us how to do inhibitor agent integration so that the toxicity of the treatment is most effective and safe for the cancer patient.

Lung Cancer Early Detection Saves Lives

The cancer research industry and medical doctors practicing lung cancer treatment will become more proficient at explaining the benefits of the complex investigation associated with lung cancer screening tests.  Primary care physicians will become more knowledgeable and comfortable with their understanding of the new research about lung cancer.  Presentations about lung cancer screening and its benefits will help persons at risk of lung cancer to have less fear about the process and discover how screening saves lives; maybe their life.  While considering the costs and benefits of lung cancer screening, one must also balance the perspective with the knowledge of 160,000 persons who die each year from lung cancer, which many might be saved by choosing lung cancer screening.

Phase II Clinical Trials of Eph-B4 to Soon Begin

Dr. Gill has several mesothelioma cancer victims currently in the Phase I clinical trial using the Eph-B4 drug, and being treated at USCNorrisComprehensiveCancerCenter in Los Angeles.  The improved results these cancer patients are displaying are very encouraging to the USC Norris cancer research team.  Consequently, Dr. Gill has recently received permission from the FDA to enter into clinical trials for Phase II.  This study will proceed and include cancer patients with mesothelioma as well as pancreatic cancer.

Contact Dr. Gill for more information: (800) 909-6376 or www.mesorfa.org (ask Dr. Gill)

Reference:

  • Dr. Parkash S. Gill is a professor of Medicine and Pathology and leads the MesoRFA.org research team.
  • The Mesothelioma Research Foundation of America has a mission: fund research that will lead to the quickest cure for mesothelioma. Since 2001, the foundation has funded the Cancer Research Laboratory under the supervision of Dr. Gill at the USC/Norris Comprehensive Cancer Center in Los Angeles.  Dr. Gill (a board certified oncologist and hematologist) has received FDA approval to provide Clinical Trials for lung cancer patients using new treatment drugs with research 100% funded by the foundation.  We are all very excited at the possibilities of a more effective treatment over what presently is available for lung cancer victims.
23 February 2014 at 01:40 - Comments

Dr. Parkash Gill and Novel Therapeutic Targets (EphB4, Axk, GRP78) in Pancreatic Cancer

English: Gene expression pattern of the EPHB4 ...

Gene expression pattern of the EPHB4 gene

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.[1][2]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.[2][3]

APA/Hirshberg Symposium: Celebrating 10 Years of the Hirshberg Seed Grant THERAPY Novel Therapeutic Targets (EphB4, Axk, GRP78) in Pancreatic Cancer Dr. Parkash Gill.

  1. Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT (Jun 1994). “Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily”. J Biol Chem 269 (19): 14211–8. PMID 8188704.
  2.  Jump up to:a b “Entrez Gene: EPHB4 EPH receptor B4″.
  3. Jump up Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999). “Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development.”. Mol. Cell 4 (3): 403–14. doi:10.1016/S1097-2765(00)80342-1PMID 10518221.
15 January 2014 at 18:12 - Comments

Useful Mesothelioma Information To Know

Mesothelioma is a rare form tumor cancer.  It refers to the cancerous tumor which primarily involves the mesothelial cells of the human organs, usually abdominal organs or lungs. Since most mesothelioma cancer cases are unsuccessful, it is just important to know some mesothelioma information to make sure you are not afflicted with this threatening disease.

Pleural mesothelioma is the common type of mesothelioma disease . This mesothelioma cancer strikes the pleura which is the membrane between the lungs and the chest cavity.  A lubricated surface to prevent the lungs from chaffing against the chest walls is provided by the membrane.  So, a pleural mesothelioma attack is also known as lung cancer.

Another form of mesothelioma cancer that frequently occurs is called  peritoneal mesothelioma. This cancer afflicts the peritoneum membrane which  encloses the abdomen organs.  Although peritoneal mesothelioma does not  occur as commonly as Pleural mesothelioma, it does tends to be more threatening and invasive.  Therefore, this may result in a shorter life period for the patient.

Mesothelioma Information – Brief History

Where does mesothelioma come from?  This is the most common question asked by persons diagnosed with mesothelioma.  The most common short  answer: exposure to airborne asbestos particles.  When a person is diagnosed this disease,  the cancer’s onset is usually found to be related to a history of asbestos exposure. Asbestos is a mineral, mined and used for many decades as a main thermal insulation material.  Since the 1920’s, it has been widely known that asbestos is a carcinogen, which can cause cancer. Still, asbestos continued to be used in many products until the early part of 1970, and consequently is found currently in many buildings today.60,000 die of asbestos mesothelioma

A unique feature of various asbestos caused diseases is that they have a long latency period.  In other words, from the day of exposure to asbestos fibers and breathing the asbestos dust and the noticeable onset of the cancerous disease can take many years.  A common latency period for mesothelioma cancer can be 20 to 50 years, and sometimes more time.  Therefore, a person can be exposed to asbestos many years ago and only now begin to show the development and signs of mesothelioma.

Clinical Signs and Symptoms of Mesothelioma

With mesothelioma, the signs and symptoms for this cancer can be very general, and unfortunately doctors have misdiagnosed and often neglected and ignored the signs.  In many cases, the signs and symptoms for this cancer type arise between 2 and 3 months before the cancer is fully diagnosed.

Making decisions about what to do with mesothelioma cancer is greatly dependent upon which stage the tumor is at upon discovery.  When you have an early diagnosis of mesothelioma than surgical intervention can sometimes prolong life expectancy.  Depending on the patient’s physical condition and age, the option for surgery may not be possible.  In addition to the option for surgery, then chemotherapy and radiation treatment may be useful in the treatment of mesothelioma.  Finally, home care and pain reduction options are common alternatives and considerations during the later stages of mesothelioma cancer before death.

Where To Go After A Diagnosis with Mesothelioma?

When a person has been diagnosed with mesothelioma, it becomes most important to understand and know the medical treatment options available for the patient.  Always contact and ask questions with an oncologist, or at least your personal doctor so they can provide you with information about mesothelioma as well as some treatment options to choose from.

If you need to speak with an oncologist, Dr. Gill with the Mesothelioma Research Foundation of America welcomes your questions and will gladly provide answers for free.  Simply click on this link and use this contact form to send the doctor your concern.

11 April 2013 at 05:15 - Comments

Mesothelioma Cancer – The Latest News

Mesothelioma kills life-long criminal and infamous author

James Fogle stole his first car at the young age of 12 and set a course for the remainder of his life that would consist of an endless string of crimes.  James, who contracted mesothelioma, spent most of his life living in a prison, and eventually died living behind bars at the age of 75 in August, 2012 probably from the malignant mesothelioma he got while working as a pipe fitter.

Fogle described himself as a restless child born in a small town in Wisconsin and lived with an abusive father.  Early in his youth, he decided that stealing cars would be a form of escapism.  Consequently, James would spend much of his life as a youth in juvenile correctional facilities.  According to his autobiographies, it was in these facilities where he learned methods from other criminal detainees on how to pull off various crimes.  As he sustained his life path of criminal behavior, after serving time in jail as an adult and learning from fellow inmates, upon his release he began robbing drugstores.  James Fogle, all his life, was in and out of prison and seldom experienced freedom for more than a year between sentence terms.James Fogle dies of mesothelioma while living in prison

During one of his prison terms, he was trained to be a steam pipe fitter.  It is suspected that during this era of his life he was exposed to asbestos, which later led to his development of mesothelioma.  When one is  exposed to asbestos fibers, some of the fibers floating in the are you breath can become trapped in the lungs when inhaled, and this can cause the deadly diseases known as mesothelioma.  Mesothelioma lung cancer is caused by exposure to floating asbestos particles.  However, with mesothelioma there is usually a latency period of 20 to 50 years from the time of exposure before the development of symptoms can be recognized.

Mesothelioma diagnosis typically begins with a sufferer’s visit to the doctor complaining of chronic chest pain. This pain is caused as a result of a buildup of fluid inside the pleural space; this is called pleural effusion and is the most common presenting symptom of malignant mesothelioma.

Preliminary mesothelioma detection can be achieved through a chest imagery scan (CT scan, x-ray); however, mesothelioma is often misdiagnosed as viral pneumonia at this stage because of certain symptomatic similarities between the two. The only way to definitively verify a suspected case of malignant mesothelioma is through a biopsy.

Because of his mesothelioma cancer condition and toward the end of his life, James was required to use an oxygen tank to breathe.

Mesothelioma kills book writer

While James  only had a sixth-grade education, he became inspired by books he read during his prison time.  From his reading he developed his own writing style, and wrote 11 autobiographical novels while doing his time.   “Drugstore Cowboy,” is the story about drug addicts who teamed up to support their drug addictions by working together to  rob  pharmacies.  This was the only book he wrote that got published.  This novel was used to create a highly-regarded and  successful film by director Gus Van Sant.  The film was made in 1989 with Matt Dillon playing the lead role.  William Burroughs, one of the major faces of the Beat Generation, had a minor role in the movie, and lauded Fogle’s novel.

At the Monroe Correctional Complex in Monroe, Washington, James Fogle was serving out his 16-year sentence for  crimes committed when he died of mesothelioma cancer.

References:

http://www.nytimes.com/2012/08/30/us/james-fogle-author-of-drugstore-cowboy-dies-at-75.html

http://articles.latimes.com/2012/aug/26/local/la-me-james-fogle-20120826

http://seattletimes.com/html/obituaries/2018979541_cowboy24m.html

21 March 2013 at 22:51 - Comments
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