MesoRFA Information and Press Releases

Useful Mesothelioma Information To Know

Mesothelioma is a rare form tumor cancer.  It refers to the cancerous tumor which primarily involves the mesothelial cells of the human organs, usually abdominal organs or lungs. Since most mesothelioma cancer cases are unsuccessful, it is just important to know some mesothelioma information to make sure you are not afflicted with this threatening disease.

Pleural mesothelioma is the common type of mesothelioma disease . This mesothelioma cancer strikes the pleura which is the membrane between the lungs and the chest cavity.  A lubricated surface to prevent the lungs from chaffing against the chest walls is provided by the membrane.  So, a pleural mesothelioma attack is also known as lung cancer.

Another form of mesothelioma cancer that frequently occurs is called  peritoneal mesothelioma. This cancer afflicts the peritoneum membrane which  encloses the abdomen organs.  Although peritoneal mesothelioma does not  occur as commonly as Pleural mesothelioma, it does tends to be more threatening and invasive.  Therefore, this may result in a shorter life period for the patient.

Mesothelioma Information – Brief History

Where does mesothelioma come from?  This is the most common question asked by persons diagnosed with mesothelioma.  The most common short  answer: exposure to airborne asbestos particles.  When a person is diagnosed this disease,  the cancer’s onset is usually found to be related to a history of asbestos exposure. Asbestos is a mineral, mined and used for many decades as a main thermal insulation material.  Since the 1920′s, it has been widely known that asbestos is a carcinogen, which can cause cancer. Still, asbestos continued to be used in many products until the early part of 1970, and consequently is found currently in many buildings today.

A unique feature of various asbestos caused diseases is that they have a long latency period.  In other words, from the day of exposure to asbestos fibers and breathing the asbestos dust and the noticeable onset of the cancerous disease can take many years.  A common latency period for mesothelioma cancer can be 20 to 50 years, and sometimes more time.  Therefore, a person can be exposed to asbestos many years ago and only now begin to show the development and signs of mesothelioma.

Clinical Signs and Symptoms of Mesothelioma

With mesothelioma, the signs and symptoms for this cancer can be very general, and unfortunately doctors have misdiagnosed and often neglected and ignored the signs.  In many cases, the signs and symptoms for this cancer type arise between 2 and 3 months before the cancer is fully diagnosed.

Making decisions about what to do with mesothelioma cancer is greatly dependent upon which stage the tumor is at upon discovery.  When you have an early diagnosis of mesothelioma than surgical intervention can sometimes prolong life expectancy.  Depending on the patient’s physical condition and age, the option for surgery may not be possible.  In addition to the option for surgery, then chemotherapy and radiation treatment may be useful in the treatment of mesothelioma.  Finally, home care and pain reduction options are common alternatives and considerations during the later stages of mesothelioma cancer before death.

Where To Go After A Diagnosis with Mesothelioma?

When a person has been diagnosed with mesothelioma, it becomes most important to understand and know the medical treatment options available for the patient.  Always contact and ask questions with an oncologist, or at least your personal doctor so they can provide you with information about mesothelioma as well as some treatment options to choose from.

If you need to speak with an oncologist, Dr. Gill with the Mesothelioma Research Foundation of America welcomes your questions and will gladly provide answers for free.  Simply click on this link and use this contact form to send the doctor your concern.

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Mesothelioma kills life-long criminal and infamous author

James Fogle stole his first car at the young age of 12 and set a course for the remainder of his life that would consist of an endless string of crimes.  James, who contracted mesothelioma, spent most of his life living in a prison, and eventually died living behind bars at the age of 75 in August, 2012 probably from the malignant mesothelioma he got while working as a pipe fitter.

Fogle described himself as a restless child born in a small town in Wisconsin and lived with an abusive father.  Early in his youth, he decided that stealing cars would be a form of escapism.  Consequently, James would spend much of his life as a youth in juvenile correctional facilities.  According to his autobiographies, it was in these facilities where he learned methods from other criminal detainees on how to pull off various crimes.  As he sustained his life path of criminal behavior, after serving time in jail as an adult and learning from fellow inmates, upon his release he began robbing drugstores.  James Fogle, all his life, was in and out of prison and seldom experienced freedom for more than a year between sentence terms.

During one of his prison terms, he was trained to be a steam pipe fitter.  It is suspected that during this era of his life he was exposed to asbestos, which later led to his development of mesothelioma.  When one is  exposed to asbestos fibers, some of the fibers floating in the are you breath can become trapped in the lungs when inhaled, and this can cause the deadly diseases known as mesothelioma.  Mesothelioma lung cancer is caused by exposure to floating asbestos particles.  However, with mesothelioma there is usually a latency period of 20 to 50 years from the time of exposure before the development of symptoms can be recognized.

Mesothelioma diagnosis typically begins with a sufferer’s visit to the doctor complaining of chronic chest pain. This pain is caused as a result of a buildup of fluid inside the pleural space; this is called pleural effusion and is the most common presenting symptom of malignant mesothelioma.

Preliminary mesothelioma detection can be achieved through a chest imagery scan (CT scan, x-ray); however, mesothelioma is often misdiagnosed as viral pneumonia at this stage because of certain symptomatic similarities between the two. The only way to definitively verify a suspected case of malignant mesothelioma is through a biopsy.

Because of his mesothelioma cancer condition and toward the end of his life, James was required to use an oxygen tank to breathe.

Mesothelioma kills book writer

While James  only had a sixth-grade education, he became inspired by books he read during his prison time.  From his reading he developed his own writing style, and wrote 11 autobiographical novels while doing his time.   “Drugstore Cowboy,” is the story about drug addicts who teamed up to support their drug addictions by working together to  rob  pharmacies.  This was the only book he wrote that got published.  This novel was used to create a highly-regarded and  successful film by director Gus Van Sant.  The film was made in 1989 with Matt Dillon playing the lead role.  William Burroughs, one of the major faces of the Beat Generation, had a minor role in the movie, and lauded Fogle’s novel.

At the Monroe Correctional Complex in Monroe, Washington, James Fogle was serving out his 16-year sentence for  crimes committed when he died of mesothelioma cancer.

References:

http://www.nytimes.com/2012/08/30/us/james-fogle-author-of-drugstore-cowboy-dies-at-75.html

http://articles.latimes.com/2012/aug/26/local/la-me-james-fogle-20120826

http://seattletimes.com/html/obituaries/2018979541_cowboy24m.html

Mesothelioma Awareness Gets A Boost On Rare Disease Day 2013

Mesothelioma awareness fits the focus of  Rare Disease Day 2013

The fifth annual U.S. Rare Disease Day was held on February 28th.  Organized and supported by the National Organization for Rare Disorders (NORD), this event has been created to direct public attention on approximately 7,000 rare diseases that affect almost 30 million people in America.  And among the rare “orphaned” disorders is Mesothelioma, the  asbestos-related cancer disease which affects one-tenth of the American population.

Orphan disease status is assigned to any disease or disorder that fewer than 200,000 people in the United States.    Mesothelioma cancer, for example, has about 3,000 people in American that are diagnosed each year with the disease.   Rare Disease Day is an international advocacy day designated to raise public awareness of rare diseases, such as Mesothelioma,  and increase recognition globally with a concern solving rare disease effects.

According to NORD president and CEO, Peter Saltonsall, “There are nearly 30 million Americans—and millions more around the world—affected by rare diseases”

“Everyone knows someone with a rare disease. But, while many of these diseases are serious and lifelong, most have no treatment and many are not even being studied by researchers. This leaves patients and families without hope for a better future.”

Because mesothelioma is relative rare, as are other orphan diseases, managing this cancer and attempting to discover  appropriate treatment is sometimes overwhelming to the patient and their family.  And based on government statistics, orphan diseases are serious or life-threatening to  85-90 percent of patients, and still as few as 200 of theses diseases  like mesothelioma have any effective treatments currently.

Mesothelioma Cancer and the National Organization for Rare Disorders

This years conference theme for 2013 is global in focus, called  “Rare Disorders Without Borders.”   The day will have special significance for the United States since this year 2013 is the 30^th anniversary of the congressional Orphan Drug Act.  Therefore, there are additional incentives that should encourage U.S. companies to develop treatments for rare diseases, as well as for  N.O.R.D. which was established in 1983 by advocates of patients with rare disorders like mesothelioma cancer.

N.O.R.D. set the 2013 program for Rare Disease Day to include activities in the U.S. that place a spotlight on awareness events at many  State Houses, a Rare Disease Research Hall of Fame, a Handprints Across America photo gallery, and an event at the National Institutes of Health (NIH) in Bethesda, MD.

Even after the passing of this special day, we still need your support and advocacy, so you still can get more information about Rare Disease Day activities for the United States at: www.rarediseaseday.us.  And additional information about global activities can be found at:  www.rarediseaseday.org.

MESOTHELIOMA DIAGNOSIS

Mesothelioma diagnosis typically begins with a sufferer’s visit to the doctor complaining of chronic chest pain. This pain is caused as a result of a buildup of fluid inside the pleural space; this is called pleural effusion and is the most common presenting symptom of malignant mesothelioma.

Preliminary mesothelioma detection can be achieved through a chest imagery scan (CT scan, x-ray); however, mesothelioma is often misdiagnosed as viral pneumonia at this stage because of certain symptomatic similarities between the two. The only way to definitively verify a suspected case of malignant mesothelioma is through a biopsy.

A biopsy is a relatively minor procedure (dependent on the location of the tumor) during which a small section of suspect tissue is removed. The removed section is examined by a histopathologist, an expert in the study of diseased tissue. Histopathological examination can confirm a case of malignant mesothelioma while also typing and staging it. Understanding the type and stage can help doctors suggest the best of treatment.

You can also have your questions about malignant mesothelioma and clinical trials for new cures, answered for free by Dr. Gill at the Mesothelioma Research Foundation of America by clicking here: Ask Dr. Gill

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Vacuum Cleaner Theft Sparks Asbestos Fears

Asbestos Fears Sparked By Vacuum Cleaner Theft

Police from Great Britain  are asking the public to help find a stolen industrial vacuum cleaner which was used to suck up and remove asbestos.  According to BBC reports, thieves broke into a construction site under renovation over the weekend in the town of Carlisle, northern England.  After moving five vacuum cleaners into another room, the robbers chose to steal a yellow Numatic cleaner.  Unfortunately,  anyone coming in contact with that cleaner will now face serious health risks  and is advised not to touch the unit because it contains asbestos.  Just three years previously, a  situation just like this occurred when burglars stole a batch of industrial vacuums from Redcar & Cleveland College in Northeast England.  According to the BBC, the police responded by releasing a warning to the public that told them not to purchase the cleaners if they were offered them.

Asbestos is Cause for Extreme Caution

When it comes to asbestos, the cause for extreme caution is warranted. According to the U.S. National Cancer Institute, there is no recognized safe level of asbestos exposure.  Inhalation of the fibrous mineral causes serious illnesses, including asbestosis, cancers of the lungs and other organs, and mesothelioma.  Asbestos is present in many older buildings in the United Kingdom and the United States.  Versatile, cheap, and flame-retardant, the fibrous mineral was used extensively in building materials until about 1980, when the dangers of inhaling the material became widely known.  Because asbestos-related diseases such as mesothelioma take decades to develop, thousands of people were exposed to the material while working on job sites.  Have you been diagnosed with mesothelioma or any other asbestos-related condition?  Do you believe you were exposed to asbestos at a job site?  Then you may be interested in having your questions about asbestos exposure and the possibility of having mesothelioma answered by Dr. Gill, here at the Mesothelioma Research Foundation of America

 

 

How Mesothelioma Might Impact Long Term Health

Mesothelioma Diagnosis

While it might seem that a diagnosis is the most important part of mesothelioma and handling your health, this is far from the case. The diagnosis is merely the starting point from which you need to begin treatment. And though your health might be something you consider to be priceless, it is also something which can be very expensive when it comes to managing mesothelioma. This is why those with mesothelioma seek legal restitution for their injuries. Though your initial diagnosis can be traumatic, the bills which come from your long term care can be catastrophic without the financial help you deserve from an employer.

Mesothelioma is a Cancer

As one of the rarest forms of cancer, mesothelioma is a condition which impacts not only the lungs, but the entire body as well. A cancer is a condition in which cells are damaged at the DNA level and then when they replicate, the cells are then damaged, causing pain, illness, and tumors. If the cells can be destroyed via radiation, chemotherapy, or other treatments, the cancer can be cured. But as mesothelioma tends to spread in the body before it is detected, it can be difficult to cure this cancer without using a combination of treatments, all of which may not completely remove the cancer from the body.

Radiation and Chemotherapy for Mesothelioma

In order to stop the spread of mesothelioma in the body, most doctors will prescribe radiation and chemotherapy treatments. While these can be wildly successful, they can also be very difficult to manage in some patients. As every patient is different and every cancer is different, you may find that your mesothelioma doesn’t respond to one treatment, but does respond to another – and of course that is the treatment which is not covered by your insurance policy. Each radiation and chemotherapy treatment can cost thousands of dollars and they need to be given regularly in order to provide the results you and your mesothelioma need.

Surgery and Combination Treatments

Sometimes, the only thing which can be done to help mesothelioma is to remove the tumors which are spreading in the body. This is painful, extensive, and possibly even debilitating if there are enough tumors which need to be removed. With the proper financial compensation for mesothelioma, you will be able to not only pay for the surgeries and their related costs, but you will also be able to pay for the pre- and post- care needs. You will be able to also have follow-up surgeries if the mesothelioma proves to be difficult to manage.

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What Causes Mesothelioma?

Mesothelioma cancer affects many former workers who were employed at factory, military, shipyard and construction projects.  Mesothelioma has been proven to be primarily caused by exposure to asbestos, even though there are other aggravating factors that also worsen a mesothelioma condition.

What is Mesothelioma?

Mesothelioma are tumors that affect the lining surrounding many of the body’s internal organs.  The tumors can cause symptoms such as severe chest pain, fatigue, anemia, low blood sugar levels, lung collapse, and shortness of breath.  Mesothelioma can also spread as tumors all over the body except for the brain, the skeletal system and the adrenal glands.  Mesothelioma symptoms will usually have a long latency time before they manifest as much as 15 to 30 years.  The cancer is difficult to treat or prevent because in most cases it is not diagnosed until decades after the patient had their initial exposure to asbestos which caused the mesothelioma tumors.

How Does Asbestos Exposure Occur?

Asbestos is the common word given to a wide range of minerals that have been used for many years of history being most recently processed for use in several industrial applications.  Asbestos is efficient as an inexpensive insulator which made it popular for use in the construction of homes created before the 1970s.  It was also applied a lot to military ships during World War II.   Asbestos in its raw mineral form has small particles which can easily become airborne, and when they are inhaled can cause a great risk to health.   Once the asbestos particles get inside the body, their abrasive dust fragments lead to the development of mesothelioma tumor cancer.  Unfortunately, there have been shipyard workers and factory people that have been exposed to the inhalation of asbestos particles long before the correlation between asbestos and mesothelioma became recognized.

What Can Be Done About Mesothelioma

Contemporary construction workers involved with the renovation of older buildings are much at risk for exposure to asbestos which induces mesothelioma.  Because mesothelioma has many symptoms that are similar to many other common diseases, its early diagnosis is very complicated to do.  A detailed review of a patient’s medical history and occupational experience is necessary to obtain an accurate diagnosis of mesothelioma.  A thorough patient medical history review is usually followed by thorough physical examinations that include chest X-rays, lung function tests and CT scans or MRIs.

Mesothelioma can be resistant to surgery, so there are few other treatments that might provide some form of cancer relief.  Chemotherapy is a common treatment administered as a recourse, and immunotherapy treatments have shown promise to provide various results of success.

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North Ireland Deaths From Mesothelioma and Asbestosis in 2012

Asbestosis Big Problem in Northern Ireland

 

The Northern Ireland General Register Office, the province’s record keeper, said that mesothelioma and asbestosis were the primary or secondary causes of some 75 deaths annually.

In little more than five years, there have been more than 300 estimated deaths in Northern Ireland from asbestos exposure, according to a U.TV article, citing a recent government report.

This government report also suggests  there were possibly another 40 lung cancer deaths each year where asbestosis or mesothelioma were contributing factors.  Mesothelioma is a rare and deadly disease that destroys the linings of the heart, lungs or abdomen.  Exposure to asbestos is nearly always the cause of mesothelioma.  And asbestosis is specifically a lung disease caused by inhaling asbestos.

The situation is serious were unlike the United States which phased out asbestos in building materials in the 1980s, asbestos continued to be used in Northern Ireland until about 2000. The Health and Safety Executive for Northern Ireland (HSENI) organization predicts the current number of deaths to rise.  It has organized free training called “Asbestos Training Pledge NI” as a response to help local construction workers protect themselves from asbestos exposure.

Asbestos is a fibrous mineral once used extensively in building materials because of its high tensile strength, durability, high availability, and low cost.   Given its’ early widespread adoption in the United States, asbestos continues to be a problem there as well.  Since the 1970s,  research has linked asbestos exposure definitively to multiple painful and deadly diseases, such as mesothelioma.

Many manufacturers knew their asbestos products posed serious health risks, but some hid this information from both their workers and the public. Have you or a loved one developed mesothelioma after exposure to asbestos while at a workplace?  If so, then call a Lawyer who is an expert in Mesothelioma and Asbestosis, and ask them for a free legal consultation about a potential mesothelioma lawsuit.

More Mesothelioma and Asbestosis Information

 

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Phase II Clinical Trials of CRS-207 New Cancer Vaccine Begin

CRS-207 Clinical Trials Proceed

The Mesothelioma Research Foundation of America is pleased to announce that Aduro Bio Tech has begun conducting phase II clinical trials on a new cancer vaccine called CRS-207.  Aduro Bio Tech has enlisted the first group of mesothelioma patients that will take the experimental vaccine.

CRS-207 comes from a relatively new field of study called Immunology that has recently been at the forefront of mesothelioma research.  Immunology is the practice of working with the bodys natural immune system to succor the body and manipulate its ability to ward off cancer cells. CRS-207 is classified as a type of immunotherapy.

CRS-207 Boosting the immune system

According to the American Cancer Society (ACS), cancer vaccines stimulate the immune system to attack diseased cells that are marked by specific antigens.  Using CRS-207, scientists also hope that this reaction will cause the immune system to remember the malignancy and prevent it from coming back.

Therapeutic vaccines are typically formulated with cancer cells, parts of cells or antigens, according to the ACS.  Aduro’s candidate treatment CRS-207 uses proprietary attenuated Listeria monocytogenes strains to trigger an immune response against mesothelin tumor-associated antigen. This protein can be found on tumors associated with mesothelioma, non-small-cell lung cancer and malignancies of the ovaries and pancreas.

The new CRS-207 drug is a derivative from a weakened version of Listeria monocytogenes, a bacteria that is the cause of a food-born illness known as Listeriosis. Scientists have manipulated the bacteria in order to generate an immune response to stop cells from producing mesothelin, a tumor-associated antigen that is produced by various types of cancer cells including those produced by mesothelioma.

Phase I of the CRS-207 vaccine trials was concluded on 17 mesothelioma patients, all of who were in various stages of the mesothelioma disease.  Although mesothelioma patients in the advanced stages face a very short life expectancy of a few months, six out of 17 patients who took the CRS-207 vaccine lived 15 months or longer.

Phase II trials will have newly diagnosed mesothelioma patients begining treatment by receiving two CRS-207 vaccinations in addition to the traditional mesothelioma chemotherapy treatment of cisplatin with pemetrexed. Once chemotherapy has concluded, the patients with receive at least two more doses of CRS-207. A group of patients with metastatic pancreatic cancer will also participate in phase two trials.

Dr. Scott Antonia of the H. Lee Moffitt Cancer Center in Tampa, Florida and Dr. Raffit Hassan of the National Cancer Institute are leading the clinical trials. Phase II trials of CRS-207 will center on testing for safety and efficacy in efforts to create the best dosage profile. Patients in the early stages of mesothelioma are currently being enrolled, with trials set to end by December 13th.

The study of Immunotherapy has been an expanding topic among leading mesothelioma researchers, with several recent developments yielding positive results among patients. Asbestos-related diseases such as mesothelioma have long been plagued with low survival rates.  Several recent developments in Immunology have produced new hope among the mesothelioma community as well as other groups in the fight against mesothelioma cancer.

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Fighting the Asbestos fibrous hazard

Asbestos fibrous hazard

The World Health Organization (WHO)  has classified asbestos as a “carcinogen” which causes lung cancer, mesothelioma and asbestosis.

“Instead of going about it in phases, India needs to completely ban mining, trade, manufacturing and use of all forms of asbestos-based products,” …

Asbestos banning

Given the health hazards that asbestos poses and the fact that International Maritime Organisation (IMO), of which India is a member state since 1959, has banned installation of all types of asbestos-containing materials as of January 1, 2011, activists have expressed “shock and surprise” over India’s willingness to accept use of asbestos in the aircraft carrier’s insulation in the boiler section.

“Though India has banned mining of asbestos, its use has not been completely stopped. Chrysotile, the most common form of asbestos, is a fibrous substance which is mixed with cement to create a fire-retardant mixture that is applied to corrugated sheets and pipes.”

Read more on The Hindu

More about asbestos products:

http://www.mesorfa.info/mesothelioma-risk-increases-along-with-consumption-of-asbestos-products/

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REVIEW: WHAT IS MESOTHELIOMA?

MESOTHELIOMA: What is it?

Mesothelioma is a rare kind of malignant cancer that arises from the cells, lining the sacs of the chest (the pleura) or the abdomen (the peritoneum). Pleural mesothelioma is the most common type usually creating symptoms within the chest space. Peritoneal mesothelioma is not common which affects the organs within the abdomen with symptoms that are associated with this body space including abdominal swelling, nausea, vomiting, and bowel obstruction. The rarest form of mesothelioma cancer is pericardial mesothelioma which involves the sac surrounding the guts.  Based on the shape of the mesothelioma cells, the specific type of mesothelioma can be diagnosed.  There are three kinds of mesothelioma cells:  epithelioid, sarcomatoid and biphasic.

MESOTHELIOMA: What Are The Causes?

Exposure to asbestos particles is the primary cause for mesothelioma cancer.  A person can get exposed by inhaling or ingesting asbestos fibers, which usually become airborne when asbestos-containing materials are disturbed as in broken for removal.  When microscopic fibers are inhaled, they’ll become lodged within the lining of the lungs and these stuck fibers fester for 15-40 years until they become recognized as pleural mesothelioma.  When asbestos is ingested, the fibers will become lodged within the lining of the abdomen and eventually cause  peritoneal mesothelioma.

MESOTHELIOMA: What Are The Symptoms?

The symptoms for mesothelioma cancer vary depending on the type and the cancer’s location.   Because the various forms of the cancer are similarity, several symptoms are common and overlapping. Many patients with mesothelioma will experience shortness of breath and general fatigue.  Additionally, acute pain can occur within the chest for patients with pleural and pericardial mesothelioma, and within the abdominal region for patients with peritoneal mesothelioma.

MESOTHELIOMA: What Are The Treatments?

There are several kinds of treatment for patients with malignant mesothelioma, and sometimes they are used in combinations of two or a lot of of those are combined within the course of treatment.

• Surgery: a pleurectomy is the surgical removal of part of the chest or abdomen lining and some of the tissues around it.  Sometimes when the mesothelioma cancer has consumed too much tissue, a lung may also be removed in an operation known as a pneumonectomy.
• Radiation Therapy: using high-dose X-rays or alternative high-energy rays to kill cancer cells and shrink tumors. Two types of radiation therapy include: external radiation where a machine outside the body is used, and internal radiation using radioisotopes where putting materials that turn out radiation through skinny tubes inserted into the body space where the cancer cells are located.
• Chemotherapy:  using chemotherapeutic agents as medication to fight the cancer.  These drugs are administered in one of two ways; 1)systemically through the bloodstream or 2)intrapleurally in the pleural cavity.  When it’s administered intrapleurally, the treatment is localized at the location of the tumor. Some of these medication are very toxic, so you must discuss their use thoroughly with your doctor.
• Clinical Trials of new treatments, some non-chemotherapy.

To learn more about mesothelioma cure research and discuss clinical trial options with Dr. Gill.

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