Tag Archives: Research

GRAPHENE strips as “flying carpets” deliver cancer cure drugs

GRAPHENE – New Research
That May Help Mesothelioma Victims


An international team of researchers has developed a drug delivery technique that utilizes GRAPHENE strips as “flying carpets” to deliver drugs to cancer cells.  The technique was found to perform better well when tested in a mouse model targeting a human lung cancer tumor.

Graphene Tests Succeed

GRAPHENE successfully proved itself in lab tests against six kinds of cancer cells. Flaked Graphene oxide preferentially hits these cancers right in the stem cells.

The Graphene strip works when a cancer drug treatment can be physically integrated and bound to it because of similar molecular structures of Graphene and the drug.  So, various drug treatments can be attached to the surface of the Graphene by a combination of amino acids known as peptides.

Dr. Parkish Gill, on behalf of the Mesothelioma Research Foundation of America will determine if there is a way to apply and proceed with his non-chemotherapy treatments using the Graphene strip technique.

Click this link to read the complete story

A List of Studies on Mesothelioma and Chromosomal Abberrations

Study #1

Specificity of asbestos-induced chromosomal aberrations in short-term cultured human mesothelial cells

Cancer Genetics and Cytogenetics
Volume 41, Issue 1, August 1989, Pages 33-39
by Kenth Olofssona and Joachim Mark
Department of Pathology and Cytogenetics, Central Hospital, Skvde, Sweden

Abstract – Short-term cultured normal human mesothelial cells were exposed for 48 hours to three different asbestos compounds, crocidiolite, chrysotile, and amosite. In the concentration used (0.01 mg/ml) all three asbestiform minerals caused, within a few days, a significant increase of cells showing numerical and/or structural abnormalities. The abnormalities were analyzed in detail using banding techniques. The results were compared with the cytogenetic observations in 52 published cases of mesotheliomas. This comparison revealed only a few similarities as regards numerical deviations. The structural rearrangements in asbestos-exposed cultures, however, in many instances involved chromosome types and chromosome regions preferentially affected in mesotheliomas.

Study #2

Recovery of ingested asbestos fibers from the gastrointestinal lymph in rats

Environmental Research Volume 22, Issue 1, June 1980, Pages 201-216
by P. Sebastien, c, R. Masse, d and J. Bignon.

Abstract – Using the transmission electron microscope, asbestos fibers have been assessed in lymph fluid collected from the thoracic lymph duct in five groups of rats previously exposed to asbestos fibers (by ingestion). Ten rats were gavaged a single dose weighing approximately 20 mg. Five were given pure UICC chrysotile A while another group of five had pure UICC crocidolite. All the rats of the chrysotile group were positive animals with recovery rate values ranging from 6.9 107 to 3 105 (90% of the fibers being recovered during the first 16 hr following the gavage). The crocidolite group had only three positive animals and lower recovery rate values of 5.7 108 to 5.6 107. A third group was fed a synthetic diet containing 1%, by weight, chrysotile with a majority of short fibers (90% below 4 m). Of the 15 rats comprising this group, 13 were positive with maximum daily recovery rates ranging from 2.1 107 to 2.1 106. A group of eight rats fed the same kind of diet but containing a higher proportion of long fibers, showed only four positive animals, however, they had higher daily recovery rates ranging from 1.9 105 to 2.1 104. No fibers were encountered in the samples of the two control rats. This study demonstrates the passage of chrysotile and crocidolite fibers across the gastrointestinal wall, with the passage rate being higher for long fibers than short ones.

Study #3

Penetration of cells by asbestos fibers

Environ Health Perspect. 1974 December; 9: 255260
by J. M. G. Davis, R. E. Bolton, and J. Garrett

Abstract – Studies on the behavior of asbestos fibers within tissues have shown that the only cells that regularly contain asbestos are macrophages and their derivatives. However, these cells actively incorporate the asbestos fibers by the process of phagocytosis, and there is little evidence of direct penetration. Examination of the gut lining after prolonged asbestos ingestion has shown no evidence of dust penetration either through or between the epithelial cells. The structure and arrangement of these cells is discussed, and it is suggested that they are exceptionally well adapted to prevent penetration by any solid material.

Study #4

Static electrification of airborne asbestos: A study of its causes, assessment and effects on deposition in the lungs of rats

American Industrial Hygiene Association Journal, Volume 42, Issue 10 October 1981, pages 711 – 721
by J. H. Vincent; W. B. Johnston; A. D. Jones; A. M. Johnston

Abstract – The paper describes a series of experiments carried out in the laboratory to investigate how asbestos fibers might become electrostatically charged during the process of being made airborne, the magnitude and polarity of the charge per fiber, and the effect on lung deposition in rats. Measurements of the penetration of fibers through an electrostatic elutriator enabled the magnitude and distribution of charge in a cloud of fibers to be quantitatively assessed. Thus it was found that a typical fiber of UICC amosite, as dispersed in a typical animal exposure chamber, carried a net charge of magnitude equivalent to about 60 electrons. The distribution of charge was bimodal, suggesting that two charging mechanisms were taking place, the main one producing net negative charge and the lesser one producing net positive charge. These were attributed to materials in the dust dispenser used and with which the fibers came into contact during dispersal. It was found that the magnitude of charge on a typical fiber could be significantly reduced by the introduction of equal numbers of positive and negative gaseous ions from an a.c. corona discharge ionizer. Finally it was found that enhancement by up to 40% of the dust deposited into the slowest clearing part of the respiratory tract of experimental rats was brought about by the electrostatic charge on the airborne fibers. The implications of this finding in the field of occupational hygiene are briefly discussed.

MesoRFA Urges Families Grieving Over The Loss Of Their Mesothelioma Patient To Support Research For A Cure

Researchers study Veglin in search of a Mesothelioma cancer cure
Researchers at MesoRFA.org

The Mesothelioma Research Foundation of America understands:

We know first-hand how horrible a mesothelioma diagnosis can be for a US Navy Veteran or an individual, and we know first-hand how hard it is for the family. Unfortunately, too many families affected by mesothelioma do not know what to do or who to call, and they simply do nothing. The Research Foundation was created to do something special through research to produce a drug that brings hope for a cure,  like Veglin.  There is also concern that many US Navy Veterans or individuals die each year from mesothelioma, because they never received proper healthcare, or the doctor simply missed the mesothelioma.

MesoRFA is working hard to be game changers for US Navy Veterans or individuals dealing with a mesothelioma diagnosis, or a family dealing with a loss of their loved one from this rare deadly disease.

Aside from US Navy Veterans, other high risk groups for mesothelioma cancer include shipyard, power plant, or oil refinery workers, plumbers, electricians, county, chemical plant, or city municipal water district workers, miners, demolition construction contractors, railroad workers, or auto brake technicians.

According to MesoRFA lead researcher and oncologist, Dr. Parkash S. Gill:

Typically the average US mesothelioma victim is about 72 years old. More often than not mesothelioma is diagnosed three, four, or even five decades after the exposure to asbestos. Regrettably mesothelioma frequently appears out of the blue. Almost all US mesothelioma victims are retired, and it’s literally the last thing they ever thought might happen to them. Most don’t exactly what mesothelioma cancer is, and it is a serious concern that hundreds of families dealing with a mesothelioma death haven’t realized that new, break through research on a cure is available for their support of future patients who will be diagnosed with this cancer.

Individuals who were exposed to asbestos and have developed symptoms of mesothelioma, lung cancer, asbestosis or another asbestos-related disease should seek a  professional medical opinion.  The Mesothelioma Research Foundation of America (a not-for-profit research organization) provides free access to our mesothelioma research team for answers to your medical questions.  Simply Ask Dr. Gil.

Mesothelioma Research Foundation of America
800-909- 6376

Mesothelioma Day: the September 26th Resolution

Mesothelimoa Day — September 26, 2010

This year, MesoRFA produced a resolution for the nation and officially launched a campaign to raise national public awareness about mesothelioma cancer and the need of more financial support to fund the research for a cure.  There is so much more research to be completed and comparatively little support from the Government specifically for treatments and a cure to mesothelioma.  There just is not enough public awareness to get the Government’s focus on this issue.

Let us show you the numbers that highlight the urgent need to raise more money for mesothelioma research, which is the sole purpose of the Mesothelioma Research Foundation of America.

Join with us to help make your city government aware of Mesothelioma with its declaration in support of this special day.  You can facilitate this movement and make September 26, 2011 the greatest awareness day.   Here’s how: MesoRFA Resolution for Mesothelioma Awareness Day